Dataset Information

A comprehensive genetic association study of Alzheimer disease in African Americans.

ABSTRACT:

Objectives

To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites.

Design

We analyzed a genome-wide set of 2.5 million imputed markers to evaluate the genetic basis of AD in an African American population.

Subjects

Five hundred thirteen well-characterized African American AD cases and 496 cognitively normal African American control subjects.

Setting

Data were collected from multiple sites as part of the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study and the Henry Ford Health System as part of the Genetic and Environmental Risk Factors for Alzheimer Disease Among African Americans (GenerAAtions) Study.

Results

Several significant single-nucleotide polymorphisms (SNPs) were observed in the region of the apolipoprotein E gene (APOE). After adjusting for the confounding effects of APOE genotype, one of these SNPs, rs6859 in PVRL2, remained significantly associated with AD (P = .0087). Association was also observed with SNPs in CLU, PICALM, BIN1, EPHA1, MS4A, ABCA7, and CD33, although the effect direction for some SNPs and the most significant SNPs differed from findings in data sets consisting of whites. Finally, using the African American genome-wide association study data set as a discovery sample, we obtained suggestive evidence of association with SNPs for several novel candidate genes.

Conclusions

Some genes contribute to AD pathogenesis in both white and African American cohorts, although it is unclear whether the causal variants are the same. A larger African American sample will be needed to confirm novel gene associations, which may be population specific.

SUBMITTER: Logue MW

PROVIDER: S-EPMC3356921 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Publications

A comprehensive genetic association study of Alzheimer disease in African Americans.

Logue Mark W MW Schu Matthew M Vardarajan Badri N BN Buros Jacki J Green Robert C RC Go Rodney C P RC Griffith Patrick P Obisesan Thomas O TO Shatz Rhonna R Borenstein Amy A Cupples L Adrienne LA Lunetta Kathryn L KL Fallin M Daniele MD Baldwin Clinton T CT Farrer Lindsay A LA

Archives of neurology 20111201 12

<h4>Objectives</h4>To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites.<h4>Design</h4>We analyzed a genome-wide set of 2.5 million imputed markers to evaluate the genetic basis of AD in an African American population.<h4>Subjects</h4>Five hundred thirteen well-characterized African American AD cases and 496 cognitively normal African American control subjects.< ...[more]

PMID: 22159054

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Dataset Information

A comprehensive genetic association study of Alzheimer disease in African Americans.

Objectives

Design

Subjects

Setting

Results

Conclusions

Publications

A comprehensive genetic association study of Alzheimer disease in African Americans.

Similar Datasets

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