Ontology highlight
ABSTRACT:
SUBMITTER: Cukier HN
PROVIDER: S-EPMC4871806 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cukier Holly N HN Kunkle Brian W BW Vardarajan Badri N BN Rolati Sophie S Hamilton-Nelson Kara L KL Kohli Martin A MA Whitehead Patrice L PL Dombroski Beth A BA Van Booven Derek D Lang Rosalyn R Dykxhoorn Derek M DM Farrer Lindsay A LA Cuccaro Michael L ML Vance Jeffery M JM Gilbert John R JR Beecham Gary W GW Martin Eden R ER Carney Regina M RM Mayeux Richard R Schellenberg Gerard D GD Byrd Goldie S GS Haines Jonathan L JL Pericak-Vance Margaret A MA
Neurology. Genetics 20160517 3
<h4>Objective</h4>To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7) gene, a known risk factor for late-onset AD.<h4>Methods</h4>Custom capture sequencing was performed on ∼150 kb encompassing ABCA7 in 40 AA cases and 37 AA controls carrying the AA risk allele (rs115550680). Association testing was performed for an ABCA7 deletion identified in large AA data sets (discovery n ...[more]