Unknown

Dataset Information

0

A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.


ABSTRACT: Context:A common single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. Objective:To determine whether Thr92AlaD2 is associated with incident Alzheimer disease (AD). Design:Population-based study; human brain tissue microarray. Setting:Community-based cohorts from Chicago and northeastern Illinois and religious clergymen from across the United States constituted the primary population. A representative sample of the U.S. population was used for secondary analyses. Participants:3054 African Americans (AAs) and 9304 European Americans (EAs). Main Outcome Measure:Incident AD. Results:In the primary population, AAs with Thr92AlaD2 had 1.3 times [95% confidence interval (CI), 1.02 to 1.68; P = 0.048] greater odds of developing AD. AAs from a second population with Thr92AlaD2 showed a trend toward increased odds of dementia (odds ratio, 1.33; 95% CI, 0.99 to 1.78; P = 0.06) and 1.35 times greater odds of developing cognitive impairment not demented (CIND; 95% CI, 1.09 to 1.67; P = 0.006). Meta-analysis showed that AAs with Thr92AlaD2 had 1.3 times increased odds of developing AD/dementia (95% CI, 1.07 to 1.58; P = 0.008). In EAs, no association was found between Thr92AlaD2 and AD, dementia, or CIND. Microarray of AA brain tissue identified transcriptional patterns linked to AD pathogenesis. Conclusions:Thr92AlaD2 was associated with molecular markers known to underlie AD pathogenesis in AAs, translating to an observed phenotype of increased odds of developing AD/dementia in AAs in these populations. Thr92AlaD2 might represent one factor contributing to racial discrepancies in incident AD.

SUBMITTER: McAninch EA 

PROVIDER: S-EPMC6276710 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.

McAninch Elizabeth A EA   Rajan Kumar B KB   Evans Denis A DA   Jo Sungro S   Chaker Layal L   Peeters Robin P RP   Bennett David A DA   Mash Deborah C DC   Bianco Antonio C AC  

The Journal of clinical endocrinology and metabolism 20180501 5


<h4>Context</h4>A common single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue.<h4>Objective</h4>To determine whether Thr92AlaD2 is associated with incident Alzheimer disease (AD).<h4>Design</h4>Population-based study; human brain tissue microarray.<h4>Setting</h4>Community-based cohorts from Chicago and northeastern Illinois and religious clergymen from across the United States  ...[more]

Similar Datasets

| S-EPMC4871806 | biostudies-literature
| S-EPMC3356921 | biostudies-literature
2018-05-18 | GSE104131 | GEO
2017-08-04 | GSE102286 | GEO
2017-07-28 | GSE101929 | GEO
| S-EPMC8238796 | biostudies-literature
| S-EPMC6119822 | biostudies-literature
| S-EPMC4970661 | biostudies-literature
2017-08-04 | GSE102287 | GEO
| S-EPMC5619051 | biostudies-literature