Ontology highlight
ABSTRACT:
SUBMITTER: Pecsi I
PROVIDER: S-EPMC3360063 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Pecsi Ildiko I Hirmondo Rita R Brown Amanda C AC Lopata Anna A Parish Tanya T Vertessy Beata G BG Tóth Judit J
PloS one 20120524 5
Thymidine biosynthesis is essential in all cells. Inhibitors of the enzymes involved in this pathway (e.g. methotrexate) are thus frequently used as cytostatics. Due to its pivotal role in mycobacterial thymidylate synthesis dUTPase, which hydrolyzes dUTP into the dTTP precursor dUMP, has been suggested as a target for new antitubercular agents. All mycobacterial genomes encode dUTPase with a mycobacteria-specific surface loop absent in the human dUTPase. Using Mycobacterium smegmatis as a fast ...[more]