Ontology highlight
ABSTRACT:
SUBMITTER: Liao JC
PROVIDER: S-EPMC3360974 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Liao Jung-Chi JC Elting Mary Williard MW Delp Scott L SL Spudich James A JA Bryant Zev Z
Journal of molecular biology 20090722 4
Myosins have diverse mechanical properties reflecting a range of cellular roles. A major challenge is to understand the structural basis for generating novel functions from a common motor core. Myosin VI (M6) is specialized for processive motion toward the (-) end of actin filaments. We have used engineered M6 motors to test and refine the "redirected power stroke" model for (-) end directionality and to explore poorly understood structural requirements for processive stepping. Guided by crystal ...[more]