Ontology highlight
ABSTRACT:
SUBMITTER: Menetrey J
PROVIDER: S-EPMC2762700 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Ménétrey Julie J Bahloul Amel A Wells Amber L AL Yengo Christopher M CM Morris Carl A CA Sweeney H Lee HL Houdusse Anne A
Nature 20050601 7043
Here we solve a 2.4-A structure of a truncated version of the reverse-direction myosin motor, myosin VI, that contains the motor domain and binding sites for two calmodulin molecules. The structure reveals only minor differences in the motor domain from that in plus-end directed myosins, with the exception of two unique inserts. The first is near the nucleotide-binding pocket and alters the rates of nucleotide association and dissociation. The second unique insert forms an integral part of the m ...[more]