Ontology highlight
ABSTRACT:
SUBMITTER: Park H
PROVIDER: S-EPMC1764864 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Park Hyokeun H Li Anna A Chen Li-Qiong LQ Houdusse Anne A Selvin Paul R PR Sweeney H Lee HL
Proceedings of the National Academy of Sciences of the United States of America 20070109 3
Myosin VI moves toward the pointed (minus) end of actin filaments, the reverse direction of other myosin classes. The myosin VI structure demonstrates that a unique insert at the end of the motor repositions its lever arm and is at least in part responsible for the reversal of directionality. However, it has been proposed that there must be additional modifications within the motor that contribute to its large step size and to the reversal of directionality. To ascertain the inherent directional ...[more]