Structural dynamics of the amyloid ?-protein monomer folding nucleus.
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ABSTRACT:
SUBMITTER: Roychaudhuri R
PROVIDER: S-EPMC3362201 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Structural dynamics of the amyloid β-protein monomer folding nucleus.
Roychaudhuri Robin R Yang Mingfeng M Condron Margaret M MM Teplow David B DB
Biochemistry 20120507 19
Alzheimer's disease (AD) is linked to the aberrant assembly of the amyloid β-protein (Aβ). The (21)AEDVGSNKGA(30) segment, Aβ(21-30), forms a turn that acts as a monomer folding nucleus. Amino acid substitutions within this nucleus cause familial forms of AD. To determine the biophysical characteristics of the folding nucleus, we studied the biologically relevant acetyl-Aβ(21-30)-amide peptide using experimental techniques (limited proteolysis, thermal denaturation, urea denaturation followed by ...[more]
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