Ontology highlight
ABSTRACT:
SUBMITTER: Xia X
PROVIDER: S-EPMC4918426 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Xia Xue X Longo Liam M LM Sutherland Mason A MA Blaber Michael M
Protein science : a publication of the Protein Society 20151210 7
The folding nucleus (FN) is a cryptic element within protein primary structure that enables an efficient folding pathway and is the postulated heritable element in the evolution of protein architecture; however, almost nothing is known regarding how the FN structurally changes as complex protein architecture evolves from simpler peptide motifs. We report characterization of the FN of a designed purely symmetric β-trefoil protein by ϕ-value analysis. We compare the structure and folding propertie ...[more]