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Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells.

ABSTRACT: The Drosophila adult posterior midgut has been identified as a powerful system in which to study mechanisms that control intestinal maintenance, in normal conditions as well as during injury or infection. Early work on this system has established a model of tissue turnover based on the asymmetric division of intestinal stem cells. From the quantitative analysis of clonal fate data, we show that tissue turnover involves the neutral competition of symmetrically dividing stem cells. This competition leads to stem-cell loss and replacement, resulting in neutral drift dynamics of the clonal population. As well as providing new insight into the mechanisms regulating tissue self-renewal, these findings establish intriguing parallels with the mammalian system, and confirm Drosophila as a useful model for studying adult intestinal maintenance.

SUBMITTER: de Navascues J

PROVIDER: S-EPMC3365418 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells.

de Navascués Joaquín J Perdigoto Carolina N CN Bian Yu Y Schneider Markus H MH Bardin Allison J AJ Martínez-Arias Alfonso A Simons Benjamin D BD

The EMBO journal 20120420 11

The Drosophila adult posterior midgut has been identified as a powerful system in which to study mechanisms that control intestinal maintenance, in normal conditions as well as during injury or infection. Early work on this system has established a model of tissue turnover based on the asymmetric division of intestinal stem cells. From the quantitative analysis of clonal fate data, we show that tissue turnover involves the neutral competition of symmetrically dividing stem cells. This competitio ...[more]

PMID: 22522699

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