Ontology highlight
ABSTRACT:
SUBMITTER: Maresso AW
PROVIDER: S-EPMC3366505 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Maresso Anthony W AW Wu Ruiying R Kern Justin W JW Zhang Rongguang R Janik Dorota D Missiakas Dominique M DM Duban Mark-Eugene ME Joachimiak Andrzej A Schneewind Olaf O
The Journal of biological chemistry 20070601 32
Sortases anchor surface proteins to the cell wall of Gram-positive pathogens through recognition of specific motif sequences. Loss of sortase leads to large reductions in virulence, which identifies sortase as a target for the development of antibacterials. By screening 135,625 small molecules for inhibition, we report here that aryl (beta-amino)ethyl ketones inhibit sortase enzymes from staphylococci and bacilli. Inhibition of sortases occurs through an irreversible, covalent modification of th ...[more]