Ontology highlight
ABSTRACT:
SUBMITTER: Gouyou B
PROVIDER: S-EPMC7558062 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Gouyou Baptiste B Millul Jacopo J Villa Alessandra A Cazzamalli Samuele S Neri Dario D Matasci Mattia M
ACS omega 20200930 40
Small ligands specific to tumor-associated antigens can be used as alternatives to antibodies for the delivery of small payloads such as radionuclides, cytotoxic drugs, and fluorophores. Their use as a delivery moiety of bioactive proteins such as cytokines remains largely unexplored. Here, we describe the preparation and in vivo characterization of the first small molecule-cytokine conjugate targeting carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma and hypoxia. Site-specific conj ...[more]