Dynamics of targeted cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Bozic I
PROVIDER: S-EPMC3372676 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Dynamics of targeted cancer therapy.
Bozic Ivana I Allen Benjamin B Nowak Martin A MA
Trends in molecular medicine 20120515 6
Targeted cancer therapies offer renewed hope for an eventual 'cure for cancer'. At present, however, their success is often compromised by the emergence of resistant tumor cells. In many cancers, patients initially respond to single therapy treatment but relapse within months. Mathematical models of somatic evolution can predict and explain patterns in the success or failure of anticancer drugs. These models take into account the rate of cell division and death, the mutation rate, the size of th ...[more]
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