Bromopyridazinedione-mediated protein and peptide bioconjugation.
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ABSTRACT:
SUBMITTER: Chudasama V
PROVIDER: S-EPMC3379626 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Bromopyridazinedione-mediated protein and peptide bioconjugation.
Chudasama Vijay V Smith Mark E B ME Schumacher Felix F FF Papaioannou Danai D Waksman Gabriel G Baker James R JR Caddick Stephen S
Chemical communications (Cambridge, England) 20110707 31
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment. ...[more]
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