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Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles.

ABSTRACT: Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates.

SUBMITTER: Kagawa N

PROVIDER: S-EPMC3380807 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles.

Kagawa Natsuko N Malerich Jeremiah P JP Rawal Viresh H VH

Organic letters 20080521 12

Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates. ...[more]

PMID: 18491859

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