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Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.

ABSTRACT: Metastasis is a complex process during which several gross cellular changes occur. Cells must dissociate from the tumor mass and gain the ability to degrade extracellular matrix and migrate in order to ultimately attach and form a satellite tumor. Regulation of the actin cytoskeleton is an indispensible aspect of cell migration, and many different factors have been implicated in this process. We identified interactions between RalA and its effectors in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. Blocking RalA-Exocyst binding caused significant morphological changes and defects in single and coordinated cell migration.

SUBMITTER: Hazelett CC

PROVIDER: S-EPMC3382198 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.

Hazelett C Clayton CC Yeaman Charles C

PloS one 20120622 6

Metastasis is a complex process during which several gross cellular changes occur. Cells must dissociate from the tumor mass and gain the ability to degrade extracellular matrix and migrate in order to ultimately attach and form a satellite tumor. Regulation of the actin cytoskeleton is an indispensible aspect of cell migration, and many different factors have been implicated in this process. We identified interactions between RalA and its effectors in the Exocyst complex as directly necessary f ...[more]

PMID: 22761837

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