Ontology highlight
ABSTRACT:
SUBMITTER: Cascone I
PROVIDER: S-EPMC2543054 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
The EMBO journal 20080828 18
The Ras family G-proteins RalA and RalB make critical non-overlapping contributions to the generation of a tumorigenic regulatory network, supporting bypass of the normal restraints on both cell proliferation and survival. The Sec6/8 complex, or exocyst, has emerged as a principal direct effector complex for Ral GTPases. Here, we show that RalA and RalB support mitotic progression through mobilization of the exocyst for two spatially and kinetically distinct steps of cytokinesis. RalA is require ...[more]