Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice.
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ABSTRACT:
SUBMITTER: Wyatt RM
PROVIDER: S-EPMC3386353 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice.
Wyatt Ryan M RM Tring Elaine E Trachtenberg Joshua T JT
Nature neuroscience 20120617 7
The stability of dendritic spines in the neocortex is profoundly influenced by sensory experience, which determines the magnitude and pattern of neural firing. By optically manipulating the temporal structure of neural activity in vivo using channelrhodopsin-2 and repeatedly imaging dendritic spines along these stimulated neurons over a period of weeks, we show that the specific pattern, rather than the total amount of activity, determines spine stability in awake mice. ...[more]
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