Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4689580 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Li Haitao H Fischle Wolfgang W Wang Wooikoon W Duncan Elizabeth M EM Liang Lena L Murakami-Ishibe Satoko S Allis C David CD Patel Dinshaw J DJ
Molecular cell 20071101 4
Human L3MBTL1, which contains three malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysines, but not trimethylated lysines, in several histone sequence contexts. In crystal structures of L3MBTL1 complexes, the monomethyl- and dimethyllysines insert into a narrow and deep cavity of aromatic residue-lined pocket 2, while a proline ring inserts into shallower pocket 1. We have also engineered a single Y to E substitution within the aromatic cage of the BPTF PHD finger, re ...[more]