Ontology highlight
ABSTRACT:
SUBMITTER: Senturia R
PROVIDER: S-EPMC3388087 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Senturia Rachel R Laganowsky Arthur A Barr Ian I Barr Ian I Scheidemantle Brooke D BD Guo Feng F
PloS one 20120702 7
Human DiGeorge Critical Region 8 (DGCR8) is an essential microRNA (miRNA) processing factor that is activated via direct interaction with Fe(III) heme. In order for DGCR8 to bind heme, it must dimerize using a dimerization domain embedded within its heme-binding domain (HBD). We previously reported a crystal structure of the dimerization domain from human DGCR8, which demonstrated how dimerization results in the formation of a surface important for association with heme. Here, in an attempt to c ...[more]