BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
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ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC3389765 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
Chen Ken K Wallis John W JW Kandoth Cyriac C Kalicki-Veizer Joelle M JM Mungall Karen L KL Mungall Andrew J AJ Jones Steven J SJ Marra Marco A MA Ley Timothy J TJ Mardis Elaine R ER Wilson Richard K RK Weinstein John N JN Ding Li L
Bioinformatics (Oxford, England) 20120504 14
<h4>Unlabelled</h4>Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here, we present a software package, BreakFusion that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity and computational efficiency.<h4>Availability</h4>http://bioinformatics.mdanderson.org/main/BreakFus ...[more]
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