Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SL
PROVIDER: S-EPMC3390740 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Johnson Stuart L SL Franz Christoph C Kuhn Stephanie S Furness David N DN Rüttiger Lukas L Münkner Stefan S Rivolta Marcelo N MN Seward Elizabeth P EP Herschman Harvey R HR Engel Jutta J Knipper Marlies M Marcotti Walter W
Nature neuroscience 20091213 1
Mammalian cochlear inner hair cells (IHCs) are specialized for the dynamic coding of continuous and finely graded sound signals. This ability is largely conferred by the linear Ca(2+) dependence of neurotransmitter release at their synapses, which is also a feature of visual and olfactory systems. The prevailing hypothesis is that linearity in IHCs occurs through a developmental change in the Ca(2+) sensitivity of synaptic vesicle fusion from the nonlinear (high order) Ca(2+) dependence of immat ...[more]