Ontology highlight
ABSTRACT:
SUBMITTER: Bittolo T
PROVIDER: S-EPMC4726391 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Bittolo Tamara T Raminelli Carlo Antonio CA Deiana Chiara C Baj Gabriele G Vaghi Valentina V Ferrazzo Sara S Bernareggi Annalisa A Tongiorgi Enrico E
Scientific reports 20160125
Loss of MeCP2 (Methyl CpG binding protein 2) in Rett syndrome (RTT) causes brain weight decrease, shrinkage of the cortex with reduced dendritic arborization, behavioral abnormalities, seizures and cardio-respiratory complications. The observed monoamine neurotransmitters reduction in RTT suggested antidepressants as a possible therapy. We treated MeCP2-null mice from postnatal-day 28 for two weeks with desipramine, already tested in RTT, or mirtazapine, an antidepressant with limited side-effec ...[more]