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Coordination of cell growth and division by the ubiquitin-proteasome system.

ABSTRACT: The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.

SUBMITTER: Benanti JA

PROVIDER: S-EPMC3398185 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Coordination of cell growth and division by the ubiquitin-proteasome system.

Benanti Jennifer A JA

Seminars in cell & developmental biology 20120419 5

The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by ...[more]

PMID: 22542766

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