Ontology highlight
ABSTRACT:
SUBMITTER: Brohawn SG
PROVIDER: S-EPMC3398507 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Brohawn Stephen G SG Schwartz Thomas U TU
Nature structural & molecular biology 20091025 11
Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport. These massive protein assemblies are modular, with a stable structural scaffold supporting more dynamically attached components. The scaffold is made from multiple copies of the heptameric Y complex and the heteromeric Nic96 complex. We previously showed that members of these core subcomplexes specifically share an ACE1 fold with Sec31 of the COPII vesicle coat, and we proposed a lattice model for the NPC based on this com ...[more]