Ontology highlight
ABSTRACT:
SUBMITTER: Byrne RD
PROVIDER: S-EPMC3404105 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Byrne Richard D RD Applebee Christopher C Poccia Dominic L DL Larijani Banafshé B
PloS one 20120724 7
The nuclear envelope (NE) breaks down and reforms during each mitotic cycle. A similar process happens to the sperm NE following fertilisation. The formation of the NE in both these circumstances involves endoplasmic reticulum membranes enveloping the chromatin, but PLCγ-dependent membrane fusion events are also essential. Here we demonstrate the activation of PLCγ by a Src family kinase (SFK1) during NE assembly. We show by time-resolved FRET for the first time the direct in vivo interaction an ...[more]