Ontology highlight
ABSTRACT:
SUBMITTER: Bulek AM
PROVIDER: S-EPMC3404460 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Bulek Anna M AM Madura Florian F Fuller Anna A Holland Christopher J CJ Schauenburg Andrea J A AJ Sewell Andrew K AK Rizkallah Pierre J PJ Cole David K DK
Journal of immunological methods 20120615 1-2
The interaction between the clonotypic αβ T cell receptor (TCR), expressed on the T cell surface, and peptide-major histocompatibility complex (pMHC) molecules, expressed on the target cell surface, governs T cell mediated autoimmunity and immunity against pathogens and cancer. Structural investigations of this interaction have been limited because of the challenges inherent in the production of good quality TCR/pMHC protein crystals. Here, we report the development of an 'intelligently designed ...[more]