Ontology highlight
ABSTRACT:
SUBMITTER: Macewan SR
PROVIDER: S-EPMC3405287 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Macewan Sarah R SR Chilkoti Ashutosh A
Nano letters 20120531 6
Cell-penetrating peptides (CPPs) are a class of molecules that enable efficient internalization of a wide variety of cargo in diverse cell types, making them desirable for delivery of anticancer drugs to solid tumors. For CPPs to be useful, it is important to be able to turn their function on in response to an external trigger that can be spatially localized in vivo. Here we describe an approach to turning on CPP function by modulation of the local density of arginine (Arg) residues by temperatu ...[more]