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Aestivation and hypoxia-related events share common silent neuron trafficking processes.

ABSTRACT: The availability of oxygen is a limiting factor for neuronal survival since low levels account not only for the impairment of physiological activities such as sleep-wake cycle, but above all for ischemic-like neurodegenerative disorders. In an attempt to improve our knowledge concerning the type of molecular mechanisms operating during stressful states like those of hypoxic conditions, attention was focused on eventual transcriptional alterations of some key AMPAergic silent neuronal receptor subtypes (GluR1 and GluR2) along with HSPs and HIF-1? during either a normoxic or a hypoxic aestivation of a typical aquatic aestivator, i.e. the lungfish (Protopterus annectens).The identification of partial nucleotide fragments codifying for both AMPA receptor subtypes in Protopterus annectens displayed a putative high degree of similarity to that of not only fish but also to those of amphibians, birds and mammals. qPCR and in situ hybridization supplied a very high (p?

SUBMITTER: Giusi G

PROVIDER: S-EPMC3407487 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Aestivation and hypoxia-related events share common silent neuron trafficking processes.

Giusi Giuseppina G Zizza Merylin M Facciolo Rosa Maria RM Chew Shit Fun SF Ip Yuen Kwong YK Canonaco Marcello M

BMC neuroscience 20120420

<h4>Background</h4>The availability of oxygen is a limiting factor for neuronal survival since low levels account not only for the impairment of physiological activities such as sleep-wake cycle, but above all for ischemic-like neurodegenerative disorders. In an attempt to improve our knowledge concerning the type of molecular mechanisms operating during stressful states like those of hypoxic conditions, attention was focused on eventual transcriptional alterations of some key AMPAergic silent n ...[more]

PMID: 22520032

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Dataset Information

Aestivation and hypoxia-related events share common silent neuron trafficking processes.

Publications

Aestivation and hypoxia-related events share common silent neuron trafficking processes.

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