Ontology highlight
ABSTRACT:
SUBMITTER: Cachope R
PROVIDER: S-EPMC3408582 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Cell reports 20120711 1
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic activation achieved via in vitro optogenetic stimulation of nucleus accumbens, a terminal field of dopaminergic neurons, elicits real-time dopamine release. This mechanism occurs via direct actions on dopamine terminals, does not require changes in ne ...[more]