Ontology highlight
ABSTRACT:
SUBMITTER: Elkins JM
PROVIDER: S-EPMC3683888 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20130517 11
The protein kinase ERK5 (MAPK7) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role mediating cell proliferation, survival, epithelial-mesenchymal transition, and angiogenesis. To date, no three-dimensional structure has been published that would allow rational design of inhibitors. To address this, we determined the X-ray crystal structure of the human ERK5 kinase domain in complex with a highly specific benzo[e]pyrimido[5,4-b]diazepine-6( ...[more]