Ontology highlight
ABSTRACT:
SUBMITTER: Singh DK
PROVIDER: S-EPMC3413146 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Singh Dharmendra Kumar DK Popuri Venkateswarlu V Kulikowicz Tomasz T Shevelev Igor I Ghosh Avik K AK Ramamoorthy Mahesh M Rossi Marie L ML Janscak Pavel P Croteau Deborah L DL Bohr Vilhelm A VA
Nucleic acids research 20120428 14
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4, are mutated in human diseases manifesting in premature aging and cancer. We are interested in determining to which extent these RecQ helicases function cooperatively. Here, we report a novel physical and functional interaction between BLM and RECQL4. Both BLM and RECQL4 interact in vivo and in vitro. We ha ...[more]