Ontology highlight
ABSTRACT:
SUBMITTER: Mendez-Bermudez A
PROVIDER: S-EPMC3510502 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Mendez-Bermudez Aaron A Hidalgo-Bravo Alberto A Cotton Victoria E VE Gravani Athanasia A Jeyapalan Jennie N JN Royle Nicola J NJ
Nucleic acids research 20120918 21
Approximately 10% of all cancers, but a higher proportion of sarcomas, use the recombination-based alternative lengthening of telomeres (ALT) to maintain telomeres. Two RecQ helicase genes, BLM and WRN, play important roles in homologous recombination repair and they have been implicated in telomeric recombination activity, but their precise roles in ALT are unclear. Using analysis of sequence variation present in human telomeres, we found that a WRN- ALT+ cell line lacks the class of complex te ...[more]