Ontology highlight
ABSTRACT:
SUBMITTER: Sidorova JM
PROVIDER: S-EPMC3551992 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Sidorova Julia M JM Kehrli Keffy K Mao Frances F Monnat Raymond R
DNA repair 20121217 2
Human WRN and BLM genes are members of the conserved RECQ helicase family. Mutations in these genes are associated with Werner and Bloom syndromes. WRN and BLM proteins are implicated in DNA replication, recombination, repair, telomere maintenance, and transcription. Using microfluidics-assisted display of DNA for replication track analysis (ma-RTA), we show that WRN and BLM contribute additively to normal replication fork progression, and non-additively, in a RAD51-dependent pathway, to resumpt ...[more]