Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Mercado M
PROVIDER: S-EPMC3415392 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Fernandez-Mercado Marta M Yip Bon Ham BH Pellagatti Andrea A Davies Carwyn C Larrayoz María José MJ Kondo Toshinori T Pérez Cristina C Killick Sally S McDonald Emma-Jane EJ Odero María Dolores MD Agirre Xabier X Prósper Felipe F Calasanz María José MJ Wainscoat James S JS Boultwood Jacqueline J
PloS one 20120809 8
Acute myeloid leukemia patients with normal cytogenetics (CN-AML) account for almost half of AML cases. We aimed to study the frequency and relationship of a wide range of genes previously reported as mutated in AML (ASXL1, NPM1, FLT3, TET2, IDH1/2, RUNX1, DNMT3A, NRAS, JAK2, WT1, CBL, SF3B1, TP53, KRAS and MPL) in a series of 84 CN-AML cases. The most frequently mutated genes in primary cases were NPM1 (60.8%) and FLT3 (50.0%), and in secondary cases ASXL1 (48.5%) and TET2 (30.3%). We showed th ...[more]