Ontology highlight
ABSTRACT:
SUBMITTER: Izawa T
PROVIDER: S-EPMC3416198 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Izawa Takashi T Zou Wei W Chappel Jean C JC Ashley Jason W JW Feng Xu X Teitelbaum Steven L SL
Molecular and cellular biology 20120521 14
RANK ligand (RANKL), by mechanisms unknown, directly activates osteoclasts to resorb bone. Because c-Src is key to organizing the cell's cytoskeleton, we asked if the tyrosine kinase also mediates RANKL-stimulated osteoclast activity. RANKL induces c-Src to associate with RANK(369-373) in an αvβ3-dependent manner. Furthermore, RANK(369-373) is the only one of six putative TRAF binding motifs sufficient to generate actin rings and activate the same cytoskeleton-organizing proteins as the integrin ...[more]