Ontology highlight
ABSTRACT:
SUBMITTER: Atasoy D
PROVIDER: S-EPMC3416931 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Atasoy Deniz D Betley J Nicholas JN Su Helen H HH Sternson Scott M SM
Nature 20120801 7410
Hunger is a complex behavioural state that elicits intense food seeking and consumption. These behaviours are rapidly recapitulated by activation of starvation-sensitive AGRP neurons, which present an entry point for reverse-engineering neural circuits for hunger. Here we mapped synaptic interactions of AGRP neurons with multiple cell populations in mice and probed the contribution of these distinct circuits to feeding behaviour using optogenetic and pharmacogenetic techniques. An inhibitory cir ...[more]