Ontology highlight
ABSTRACT:
SUBMITTER: Higginbotham JN
PROVIDER: S-EPMC3417320 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Higginbotham James N JN Demory Beckler Michelle M Gephart Jonathan D JD Franklin Jeffrey L JL Bogatcheva Galina G Kremers Gert-Jan GJ Piston David W DW Ayers Gregory D GD McConnell Russell E RE Tyska Matthew J MJ Coffey Robert J RJ
Current biology : CB 20110421 9
Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen. We identify a new mode of EGFR ligand signaling via exosomes. Human breast and colorectal cancer cells release exosomes containing full-length, signaling-competent EGFR ligands. Exosomes isolated from MDCK cells expressing individual full-length EGFR ligands displayed ...[more]