Ontology highlight
ABSTRACT:
SUBMITTER: Harada Y
PROVIDER: S-EPMC3418773 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Harada Yosuke Y Tanaka Yoshihiko Y Terasawa Masao M Pieczyk Markus M Habiro Katsuyoshi K Katakai Tomoya T Hanawa-Suetsugu Kyoko K Kukimoto-Niino Mutsuko M Nishizaki Tomoko T Shirouzu Mikako M Duan Xuefeng X Uruno Takehito T Nishikimi Akihiko A Sanematsu Fumiyuki F Yokoyama Shigeyuki S Stein Jens V JV Kinashi Tatsuo T Fukui Yoshinori Y
Blood 20120328 19
To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and follow the path of least resistance. It is known that this amoeboid migration of DCs requires Cdc42, yet the upstream regulators critical for localization and activation of Cdc42 remain to be determined. Mutations of DOCK8, a member of the atypical guanine nucleotide exchange factor family, causes combined immunodeficiency in humans. In the pr ...[more]