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Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution.

ABSTRACT: Nanoparticles for cancer therapy and imaging are designed to accumulate in the diseased tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their size to about 100nm. Here, using intravital microscopy and elemental analysis, we compare the in vivo localization of particles with different geometries and demonstrate that plateloid particles preferentially accumulate within the tumor vasculature at unprecedented levels, independent of the EPR effect. In melanoma-bearing mice, 1000×400nm plateloid particles adhered to the tumor vasculature at about 5% and 10% of the injected dose per gram organ (ID/g) for untargeted and RGD-targeted particles respectively, and exhibited the highest tumor-to-liver accumulation ratios (0.22 and 0.35). Smaller and larger plateloid particles, as well as cylindroid particles, were more extensively sequestered by the liver, spleen, and lungs. Plateloid particles appeared well-suited for taking advantage of hydrodynamic forces and interfacial interactions required for efficient tumoritropic accumulation, even without using specific targeting ligands.

SUBMITTER: van de Ven AL

PROVIDER: S-EPMC3422657 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution.

van de Ven Anne L AL Kim Pilhan P Haley O'Hara O Fakhoury Jean R JR Adriani Giulia G Schmulen Jeffrey J Moloney Padraig P Hussain Fazle F Ferrari Mauro M Liu Xuewu X Yun Seok-Hyun SH Decuzzi Paolo P

Journal of controlled release : official journal of the Controlled Release Society 20111026 1

Nanoparticles for cancer therapy and imaging are designed to accumulate in the diseased tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their size to about 100nm. Here, using intravital microscopy and elemental analysis, we compare the in vivo localization of particles with different geometries and demonstrate that plateloid particles preferentially accumulate within the tumor vasculature at unprecedented levels, independent of the EPR effect. In melanoma-b ...[more]

PMID: 22062689

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Dataset Information

Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution.

Publications

Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution.

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