Ontology highlight
ABSTRACT:
SUBMITTER: Kodela R
PROVIDER: S-EPMC3423220 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Kodela Ravinder R Chattopadhyay Mitali M Kashfi Khosrow K
ACS medicinal chemistry letters 20120128 3
A series of new hybrids of aspirin (ASA), bearing both nitric oxide (NO) and hydrogen sulfide (H(2)S)-releasing moieties were synthesized and designated as NOSH compounds (1-4). NOSH-1 (4-(3-thioxo-3H-1,2-dithiol-5-yl) phenyl 2-((4-(nitrooxy)-butanoyl)oxy) benzoate); NOSH-2 (4-(nitrooxy)butyl (2-((4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)carbonyl)phenyl)); NOSH-3 (4-carbamothioylphenyl 2-((4-(nitrooxy)butanoyl)-oxy)benzoate); and NOSH-4 (4-(nitrooxy)butyl 2-(5-((R)-1,2-dithiolan-3-yl)pentanoyloxy ...[more]