Nitric Oxide-Releasing Alginates.
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ABSTRACT:
SUBMITTER: Ahonen MJR
PROVIDER: S-EPMC6759059 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Nitric Oxide-Releasing Alginates.
Ahonen Mona Jasmine R MJR Suchyta Dakota J DJ Zhu Huanyu H Schoenfisch Mark H MH
Biomacromolecules 20180326 4
Low and high molecular weight alginate biopolymers were chemically modified to store and release potentially therapeutic levels of nitric oxide (NO). Carbodiimide chemistry was first used to modify carboxylic acid functional groups with a series of small molecule alkyl amines. The resulting secondary amines were subsequently converted to N-diazeniumdiolate NO donors via reaction with NO gas under basic conditions. NO donor-modified alginates stored between 0.4-0.6 μmol NO·mg<sup>-1</sup>. In aqu ...[more]
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