Nitric Oxide-Releasing Cyclodextrins.
Ontology highlight
ABSTRACT:
SUBMITTER: Jin H
PROVIDER: S-EPMC6790977 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Nitric Oxide-Releasing Cyclodextrins.
Jin Haibao H Yang Lei L Ahonen Mona Jasmine R MJR Schoenfisch Mark H MH
Journal of the American Chemical Society 20181016 43
A series of secondary amine-modified cyclodextrin (CD) derivatives was synthesized with diverse exterior terminal groups (i.e., hydroxyl, methyl, methoxyl, and primary amine). Subsequent reaction with nitric oxide (NO) gas under alkaline conditions yielded N-diazeniumdiolate-modified CD derivatives. Adjustable NO payloads (0.6-2.4 μmol/mg) and release half-lives (0.7-4.2 h) were achieved by regulating both the amount of secondary amine precursors and the functional groups around the NO donors. T ...[more]
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