Ontology highlight
ABSTRACT:
SUBMITTER: Spehalski E
PROVIDER: S-EPMC3427096 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Spehalski Elizabeth E Kovalchuk Alexander L AL Collins John T JT Liang Genqing G Dubois Wendy W Morse Herbert C HC Ferguson David O DO Casellas Rafael R Dunnick Wesley A WA
Proceedings of the National Academy of Sciences of the United States of America 20120806 34
Many tumors are characterized by recurrent translocations between a tissue-specific gene and a proto-oncogene. The juxtaposition of the Ig heavy chain gene and Myc in Burkitt's lymphoma and in murine plasmacytoma is a classic example. Regulatory elements within the heavy chain constant region locus are required for Myc translocation and/or deregulation. However, many genes are regulated by cis-acting elements at distances up to 1,000 kb outside the locus. Such putative distal elements have not b ...[more]