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Nickel-catalyzed amination of aryl sulfamates and carbamates using an air-stable precatalyst.

ABSTRACT: A facile nickel-catalyzed method to achieve the amination of synthetically useful aryl sulfamates and carbamates is reported. Contrary to most Ni-catalyzed amination reactions, this user-friendly approach relies on an air-stable Ni(II) precatalyst, which, when employed with a mild reducing agent, efficiently delivers aminated products in good to excellent yields. The scope of the method is broad with respect to both coupling partners and includes heterocyclic substrates.

SUBMITTER: Hie L

PROVIDER: S-EPMC3427767 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Nickel-catalyzed amination of aryl sulfamates and carbamates using an air-stable precatalyst.

Hie Liana L Ramgren Stephen D SD Mesganaw Tehetena T Garg Neil K NK

Organic letters 20120731 16

A facile nickel-catalyzed method to achieve the amination of synthetically useful aryl sulfamates and carbamates is reported. Contrary to most Ni-catalyzed amination reactions, this user-friendly approach relies on an air-stable Ni(II) precatalyst, which, when employed with a mild reducing agent, efficiently delivers aminated products in good to excellent yields. The scope of the method is broad with respect to both coupling partners and includes heterocyclic substrates. ...[more]

PMID: 22849697

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