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Nickel-catalyzed amination of aryl carbamates and sequential site-selective cross-couplings.

ABSTRACT: We report the amination of aryl carbamates using nickel-catalysis. The methodology is broad in scope with respect to both coupling partners and delivers aminated products in synthetically useful yields. Computational studies provide the full catalytic cycle of this transformation, and suggest that reductive elimination is the rate-determining step. Given that carbamates are easy to prepare, robust, inert to Pd-catalysis, and useful for arene functionalization, these substrates are particularly attractive partners for use in synthesis. The sequential use of carbamate functionalization/site-selective cross-coupling processes highlights the utility of this methodology.

SUBMITTER: Mesganaw T

PROVIDER: S-EPMC6520651 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Nickel-catalyzed amination of aryl carbamates and sequential site-selective cross-couplings.

Mesganaw Tehetena T Silberstein Amanda L AL Ramgren Stephen D SD Fine Nathel Noah F NF Hong Xin X Liu Peng P Garg Neil K NK

Chemical science 20110609 9

We report the amination of aryl carbamates using nickel-catalysis. The methodology is broad in scope with respect to both coupling partners and delivers aminated products in synthetically useful yields. Computational studies provide the full catalytic cycle of this transformation, and suggest that reductive elimination is the rate-determining step. Given that carbamates are easy to prepare, robust, inert to Pd-catalysis, and useful for arene functionalization, these substrates are particularly a ...[more]

PMID: 31105924

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