Endosomal crosstalk: meeting points for signaling pathways.
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ABSTRACT:
SUBMITTER: Palfy M
PROVIDER: S-EPMC3430897 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Endosomal crosstalk: meeting points for signaling pathways.
Pálfy Máté M Reményi Attila A Korcsmáros Tamás T
Trends in cell biology 20120714 9
Endocytosis participates in downregulating incoming signals, but 'signaling endosomes' may also serve as physical platforms for crosstalk between signaling pathways. Here, we briefly review the role of endosomes in signaling crosstalk and suggest that endosome-associated scaffold proteins mediate this crosstalk. In addition, using a proteome-wide in silico approach - in which we analyze endosome-binding properties and the capacity of candidates to recruit signaling proteins from more than one di ...[more]
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