Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology.
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ABSTRACT:
SUBMITTER: van Wijk R
PROVIDER: S-EPMC5155565 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology.
van Wijk Roeland R Tans Sander J SJ ten Wolde Pieter Rein PR Mashaghi Alireza A
Scientific reports 20150618
Currently, drug discovery approaches commonly assume a monotonic dose-response relationship. However, the assumption of monotonicity is increasingly being challenged. Here we show that for two simple interacting linear signaling pathways that carry two different signals with different physiological responses, a non-monotonic input-output relation can arise with simple network topologies including coherent and incoherent feed-forward loops. We show that non-monotonicity of the response functions ...[more]
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