Ontology highlight
ABSTRACT:
SUBMITTER: Ruigrok VJ
PROVIDER: S-EPMC3431876 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ruigrok Vincent J B VJB Levisson Mark M Hekelaar Johan J Smidt Hauke H Dijkstra Bauke W BW Van der Oost John J
International journal of molecular sciences 20120822 8
Aptamers are oligonucleotide ligands, either RNA or ssDNA, selected for high-affinity binding to molecular targets, such as small organic molecules, proteins or whole microorganisms. While reports of new aptamers are numerous, characterization of their specific interaction is often restricted to the affinity of binding (K(D)). Over the years, crystal structures of aptamer-protein complexes have only scarcely become available. Here we describe some relevant technical issues about the process of c ...[more]