Ontology highlight
ABSTRACT:
SUBMITTER: Holcomb J
PROVIDER: S-EPMC5645037 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Holcomb Joshua J Spellmon Nicholas N Zhang Yingxue Y Doughan Maysaa M Li Chunying C Yang Zhe Z
AIMS biophysics 20170926 4
To date, X-ray crystallography remains the gold standard for the determination of macromolecular structure and protein substrate interactions. However, the unpredictability of obtaining a protein crystal remains the limiting factor and continues to be the bottleneck in determining protein structures. A vast amount of research has been conducted in order to circumvent this issue with limited success. No single method has proven to guarantee the crystallization of all proteins. However, techniques ...[more]